ANTI-PROLIFERATION EFFECT AND INDUCTION PPARG EXPRESSION OF HUMAN CERVICAL CANCER CELLS BY COMBINATION OF GRAPE LEAF ETHANOL EXTRACT AND CISPLATIN
نویسندگان
چکیده
This study aims to analyze the combination of grape leaf ethanol extract ( Vitis vinifera ) and cisplatin increase peroxisome proliferator-activated receptor gamma (PPARγ) expression inhibit HeLa cell proliferation in vitro. research described a new therapy method. included cytotoxicity test, test with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) Assay, PPARγ using immunofluorescence The anticancer effects (2.5, 5, 10 mg/mL) were studied through phytochemical assays. In this study, increased significantly mg/mL + cisplatin. proved be more effective than single (p < 0.05). Cisplatin polyphenolic active compounds (phenolics) can cervical cancer cells. Combination inhibited survival Keywords: Grape Leaves, Cell Proliferation, Ethanol Extract, PPARγ, Phenolic Test DOI： https://doi.org/10.35741/issn.0258-2724.58.3.13
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ژورنال
عنوان ژورنال: Xinan Jiaotong Daxue Xuebao
سال: 2023
ISSN: ['0258-2724']
DOI: https://doi.org/10.35741/issn.0258-2724.58.3.13